Senior Scientist – Biophysics

We are seeking an outstanding scientist with experience in a range of biophysical techniques to join Curve Therapeutics, an innovative, venture-backed start-up company based in Southampton, UK. The successful applicant will become part of a multidisciplinary team that is discovering and developing innovative therapeutics for the treatment of cancer.

The candidate will be employed as a Senior Scientist by Curve Therapeutics at the company’s laboratories in Southampton. Curve is a spin-out from the laboratory of Professor Ali Tavassoli, who has pioneered innovative approaches to targeting protein-protein interactions. The platform has been used to identify and report a number of cell-active, first in class inhibitors (including Miranda et al., 2013, J. Am. Chem. Soc. 135, 10418, Leitch et al., 2018, Chem. Sci. 9, 5957 and Tavassoli, 2017, Curr. Opin. Chem. Biol. 38, 30).

Responsibilities will include:

  • Run molecular biophysical methods including using SPR (Surface Plasmon Resonance), ITC (Isothermal Titration Calorimetry) and MST (Microscale thermophoresis).
  • Design and develop new biophysical assays.
  • Conduct research into protein-ligand interaction to support drug discovery projects.
  • Work collaboratively across different disciplines including chemistry and biology.


  • Will be PhD or Masters qualified in a Life Science subject such as Biophysics, Biochemistry or Biology and have experience in biophysical techniques such as SPR (Surface Plasmon Resonance) and ITC (Isothermal Titration Calorimetry).
  • Expertise in other biophysical techniques and protein production methods is advantageous.
  • Proficiency in providing quantitative data on protein-ligand binding, including affinity, kinetics, and stoichiometry.
  • Excellent communication skills, both verbal and written, with the ability to effectively present complex data to diverse audiences.
  • Ideally prior research experience within industry.

The post is available to start immediately, and the company will offer a competitive salary, dependent on experience. This is a unique opportunity to be involved in an exciting start-up venture and to contribute to and shape world-leading drug discovery efforts. 

Click on the link to apply online:


Please note we do not accept referrals from recruitment agencies


Ref: CUR-004-0324